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Both -MSH and ET-1 upregulate the expression of MCR1 and positively influence pigmentation [63]

Therefore, developing a comprehensive therapeutic platform capable of spatiotemporal ROS scavenging, regulation of macrophage polarization, and enhancement of angiogenesis and cell proliferation represents a critical research focus for improving clinical outcomes in chronic diabetic wound management

10.1007/s00404-017-4613-4 34 ChoiJ.JoM.LeeE.ChoiD

As for the other essential trace elements, dietary Se needs to reach effective concentrations in the central nervous system (CNS) to exert its functions