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of cycles 119 118 119 Age (years) 30.76 4.21 29.99 3.65 30.38 2.98 0.266 BMI (kg/m2)24.36 4.18 22.92 3.40*1 22.77 3.52*2 0.001 Infertility duration (years) 3.37 2.65 2.71 2.00 3.27 2.69 0.089 AMH (ng/ml) 3.88 3.17 4.64 3.92 5.12 4.30*3 0.044 AFC 13.50 4.68 14.82 6.13 14.52 6.10 0.173 Baseline FSH (mIU/ml) 7.08 1.79 6.80 1.62 7.11 1.59 0.296 Baseline LH (mIU/ml) 5.97 3.87 5.04 2.89 5.84 3.33 0.075 Baseline E2(pg/ml) 48.40 34.85 44.45 27.82 47.34 30.29 0.604 Baseline P (ng/ml) 0.57 0.45 0.65 0.50 0.62 0.44 0.377 Infertility type, n (%) 0.224 Primary 47 (39.50%) 57 (48.72%) 59 (49.58%) Secondary 72 (60.50%) 60 (51.28%) 60 (50.42%) Infertility factors, n (%) 0.111 Ovulation disorder 104 (87.39%) 95 (80.51%) 91 (76.47%) Pelvic and tubal factors 10 (8.40%) 17 (14.41%) 15 (12.61%) Male factor 5 (4.20%) 6 (5.08%) 13 (10.92%) Compared wi th the Low group, *1P=0.004, *2P= 0.002, *3P = 0

Recent advances in the development of protein-protein interactions modulators: mechanisms and clinical trials