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Categories of genetically-determined ancestry in All of Us corresponded directly to categorical ancestry definitions used within gnomAD 11 , the Human Genome Diversity Project 12 , and 1000 Genomes 10 : African/African American, Admixed American/Latino, East Asian, European, Middle Eastern, South Asian, and Other (meaning an individuals predominant ancestry is 0.1 were considered closely related, and to ensure independence of observations, one individual from each related pair was randomly retained

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