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These observations clearly highlight the critical need for more accurate and predictive microphysiological systems (MPS) that better mimic the human liver environment to eliminate false positive and false negative DILI as early as possible in the drug development process

Interestingly, we found that only VitB12 levels were significantly increased in the insomniac group and independently associated with the presence of insomnia after adjusting for confounding factors (which differed between the two groups and have been shown to impair sleep)

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