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Dietary intake is significant, particularly in those who follow vegan or vegetarian diets, as B12 is primarily found in animal products

By disrupting gut microbial balance, compromising barrier integrity, and amplifying inflammatory signaling, chronic stress and mental health disorders exacerbate kidney dysfunction in CKD patients (Drew et al., 2019

In terms of alterations in the activity of ERs, an overexpression of ER and a downregulation of ER have been observed in endometriosis [34]

Following a catalytic turnover, the product glutamate has a relatively low affinity for the enzyme and no longer interacts with Tyr182 and Glu314