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10.1152/physiolgenomics.00070.2018 90

Glaucoma, a prevalent ocular disorder characterized by elevated intraocular pressure (IOP) and subsequent optic nerve damage, poses a substantial global health concern

They also observed reduced translocation of p65 to nucleus thus reducing NF- mediated activation of various pro-inflammatory genes including TNF-, IL-17, IL-6, and IL-1 within arthritic joint microenvironment where they can influence osteoclast differentiation thus promoting joint destruction