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Abstract : This is a report of the reversal of two cases of scleroderma, the first case that of a fifty year old white female with severe kidney involvement, treated with intravenous EDTA and DMSO therapy, and Metranidazole and Allopurinol tablets (according to the Rheumatoid Disease Foundation protocol)

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In this context, different natural products emerge as potential agents for reducing GO, such as antioxidant compounds and their great capacity for removing and/or stabilizing oxygenated groups present in GO