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Given the prominence of circadian dysregulation in cyclical mood disorders, the involvement of these genes in the condition seems plausible

This process is not regulated by feed back inhibition and allows the excessive build-up of cholesterol inside the cells, leading to their transformation into foam cells that are involved in the initiation and progression of atherosclerotic lesion [Parthasarathy et al., 1999

Accordingly, AP translation will require not only conventional toxicology but also pancreas-relevant assessment of carrier chemistry, dosing, and timing relative to the onset of mitochondrial depolarization

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