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Other symptoms of vitamin B12 deficiency Bupa lists other signs to watch out for: Feeling very tired Breathlessness even after little exercise Heart palpitations Headaches A reduced appetite A sore mouth and tongue The health organisation adds: If you have vitamin B12 deficiency you may also look pale or jaundiced (have a yellowy tinge to your skin and the whites of your eyes). Its important to note these symptoms arent always due to vitamin B12 deficiency, but if you experience them you should still see your GP