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From a physiological perspective, DA Gsta4 did not show obvious phenotypic characteristics in terms of behavior, general health, spontaneous tumors, weight, fertility or litter size as compared to wild type animals (DA Wt )

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25 A growing body of evidence suggests that CTR1 transports Cu + , and Ctr1 may function together with metalloreductases such as STEAP and/or DCYTB to transport Cu across the membrane 26,27 (Fig