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In this context, natural compounds such as polyphenols have emerged as promising candidates due to their multifaceted mechanisms of action, including antioxidant, antiinflammatory, and neuroprotective properties

Because of the risks of addiction, abuse, misuse, overdose, and death, which can occur at any dosage or duration and persist over the course of therapy, [see WARNINGS], reserve opioid analgesics, including hydrocodone bitartrate and acetaminophen tablets, for use in patients for whom alternative treatment options are ineffective, not tolerated, or would be otherwise inadequate to provide sufficient management of pain

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