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Below, we examine key mechanisms underlying neuronal degeneration, highlighting how they drive cellular damage (Figure 1)

The majority of children who develop MIS-C (Figure 3D) present with distinctive characteristics, such as pronounced cardiac and gastrointestinal involvement and less frequent or milder involvement of other systems ( 2.3 The pathophysiology and key of cytokine storms to determine COVID-19 Proliferating lung epithelial cells, which are the initial vectors for virus infection, can attack other cells, including pulmonary macrophages (Liu et al., 2016)

Meanwhile, CHE also suppressed NF-B and AP-1, which was demonstrated by the decreased expressions of p-p65, c-Jun protein expression, and c-Fos (Yang et al., 2020)

A description of questionnaires and cognitive tasks is available in Supplementary Table 1