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2015 May;40(6):1405-16

Crocker LS Ionization Behavior of Amino Lipids for siRNA Delivery: Determination of Ionization Constants, SAR, and the Impact of Lipid pKa on Cationic Lipid-Biomembrane Interactions

(A) Cells were stained with rabbit anti-TGN46 with AlexaFluor-555 conjugated anti-rabbit secondary (red), and EdU-labeled vDNA was stained with Click-iT EdU AlexaFluor-488 (green)

5.6 What has actually worked in PC nanomedicine and why (and what failed) Despite thousands of preclinical studies and significant investments in the clinical translation of nanomedicines for PC, only two nanoformulations, namely nanoparticle albumin-bound paclitaxel (nab-paclitaxel, Abraxane ) and nanoliposomal irinotecan (Onivyde ), have been approved by the FDA and EMA for the treatment of pancreatic cancer (PC) (124,181)