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It is believed that early stages of frailty are amenable to interventions that could avert adverse outcomes, including the increased risk of hospitalization and premature death (116)

Notably, the mitochondrial pyruvate carrier serves as the sole entry point for the entry of pyruvate into mitochondria

Parker N, Laychur A, Sukwani M, Orwig KE, Oatley JM, Zhang C, Rutaganira FU, Shokat K, Wright WW (2021) Spermatogonial stem cell numbers are reduced by transient inhibition of GDNF signaling but restored by self-renewing replication when signaling resumes