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It has been reported that MOTS-c improves age-related insulin resistance in male mice by increasing glucose intake in soleus muscles (20)

10.1016/j.lfs.2020.117581 181 MakvandiP.AliG

Out of the three options, Thesis has an edge here because it uses some shorter lists of ingredients in doses that are sometimes lower than what human studies confirm to be effective

Cells were resuspended in a Low Salt Lysis Buffer (20 mM Tris-HCl, pH 8.0, 150 mM NaCl, 1 mM PMSF, and 3 mM 2-mercaptoethanol), lysed by sonication, and the soluble fraction isolated by centrifugation and incubated with low-density nickel agarose beads (GoldBio)