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UV irradiation induces DNA damage that can lead to nucleotide alterations and beneficial mutations (Lawrence et al., 1982)

Indeed, SLC1A5 is highly expressed in various solid cancers 73,76,77 , such as squamous lung cancer, in which it is responsible for approximately 50% of glutamine uptake 73

In spite of 40 years of research the exact function of this protein is more complex than ever, but it has been found that these intracellular dimeric proteins, play a major role in the intracellular transport of endogenous compounds, metabolizes various electrophilic xenobiotics, ligand transport and thus protects cells against toxic effects [31], [87], [85]

doi: 10.1016/j.jfca.2017.01.001