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Chronic ethanol exposure reduces tryptophan hydroxylase (TPH2) activitythe rate-limiting enzyme in 5-HT synthesisin the dorsal raphe nuclei (DRN) of rodents, leading to depleted 5-HT levels in the prefrontal cortex (PFC) and amygdala

When this occurs, additional free radicals are produced, which in turn can result in more extensive damage to cells and tissues

As we begin diving in remote locations at these higher altitudes, the susceptibility of DCS increases considerably due to the sudden decompression that occurs immediately after breaking the surface