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Although traditionally associated with neuronal neurotransmitter metabolism, MAO-B is expressed predominantly (if not exclusively) in astrocytes, where it plays a central role in reactive astrogliosis and neuroinflammation 345,346

In PD, GSH impacts the degeneration of dopaminergic neurons

CMS has also said it expects to revisit lifestyle support requirements annually and may shift responsibility to states and MA-PD plans in future years