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The transcriptional regulation of PPAR on carnitine homeostasis related genes is consistent with their basic role in fatty acid catabolism (85)

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Zhang, J., Jin, H., Xu, Y

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Prior to the initiation of valproic acid therapy, evaluation for UCD should be considered in the following patients: 1) those with a history of unexplained encephalopathy or coma, encephalopathy associated with a protein load, pregnancy-related or postpartum encephalopathy, unexplained mental retardation, or history of elevated plasma ammonia or glutamine

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