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Prostaglandins Leukot Essent Fatty Acids 81:253264

The lack of exon 23a in neurons specifically results in defective associative fear learning and spatial memory in mouse models ( Nf1 also has a critical role in synaptic plasticity and learning behavior in the central nervous system ( Nf1 -exon 9a in a transgenic mouse model leads to spatial learning and hippocampal plasticity deficits ( Osseous Lesions Orthopedic manifestations, including scoliosis, osteoporosis, skull defects, tibial dysplasia, and pseudarthrosis, as well as reduction in musculature strength, have been reported to affect ~50% of patients with NF1 (82, 83)

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