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If statistical differences were detected, between-group comparisons were carried out using the Fishers Least Significant Difference test

Due to the compartmentalization of mammalian cells, the NAD + recycling pathway is much more complex in mammals than in prokaryotes

In vehicle-treated rats, fentanyl elicited (1) an increase in TFL, (2) decreases in pH, pO 2 and sO 2 and increases in pCO 2 (all indicative of ventilatory depression), (3) an increase in Alveolar-arterial gradient (indicative of a mismatch in ventilation-perfusion in the lungs), and (4) changes in ventilatory parameters such as a reduction in tidal volume, that were indicative of pronounced ventilatory depression

Carnitine supplementation in IEM patients is a more routine tool but is indeed controversial