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The catalytic core of tyrosinase is composed of H 2 L 2 tetramer, and its active center contains binuclear copper ions, which form a six-coordinated chelating structure through His61, His85, His94(CuA), His259, His263 and His296(CuB) (Baskaran et al., 2021)

As the global population ages, the prevalence of AD is rapidly increasing, imposing a significant burden on patients, caregivers, and healthcare systems

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In a normal oxygenated tissue, the exposed Salmonella are vulnerable to being neutralized by the host immune system ( Salmonella in the TME ( 2.2 Passive accumulation and vascular effects In addition to active chemotaxis, the pathophysiological characteristics of the tumor vasculature also support bacterial enrichment through passive transport-related mechanisms and vascular effects