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Quality weight gain should include increases in lean muscle mass, not just overall body weight

After anesthetizing the rats with isoflurane inhalation, a wire ligation with a diameter of 0.25 mm was inserted through the distal proximal surface of the maxillary second molar of the rats, circumvented around the neck of the molar, and carried out through the mesial proximal surface of the molar

Additionally, it has also been suggested that altering the epigenetic landscapes by DNA methylation (histone/non-histone changes) aids in the maintenance and survival of CSCs which have been shown to exhibit resistance features at the individual level [76]

Increased accumulation of phenolic compounds under biotic also as abiotic stress has been demonstrated and certain anthocyanins and flavanols have up to fourfold higher antioxidative activity than Asc (Rice-Evans et al., 1996)