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Importantly, while the up-regulation of ribosomal and functional genes tightly correlates with stress mitigation, the current correlative evidence cannot definitively distinguish whether this transcriptomic shift acts as the primary driver of functional repair or emerges as a secondary consequence of the plants overall improved physiological health

doi: 10.1016/j.bbi.2020.07.036 371 LeeYZChengSHChangMYLinYFWuCCTsaiYC

The difference in the RP24 distributions between young and old fly transcriptomes is explained by numerous individual transcripts that gain or lose rhythmicity with age