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PMID: 38237593 Nat Cell Biol2020 Dec;22(12):1447-1459

In addition to miRNA, other epigenetic markers, such as histone post-translational modifications and DNA methylation, also hold potential as signature diagnostic indicators

Another new insight came from knock-out of the mysterious type 2 IGF receptor, identical to the mannose-6 phosphate receptor (M6P-R), specifically binding IGF-II and involved in internalization of proteins for lysosomal degradation

Although its tumoricidal properties hold therapeutic promise, its clinical application in lower gastrointestinal diseases and cancers remains challenging