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Once secreted, Wnts bind to the transmembrane Frizzled (FZD) receptors and coreceptors low-density lipoprotein receptor-related proteins 5/6 (LRP5/6), recruiting cytoplasmic Disheveled (Dvl) proteins, leading to the phosphorylation of LRP5/6 and attract the Axin complex to the plasma membrane

Ensembl 2020

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Typical features include: Winter flares, improving in summer Minimal itch most of the time Combination oily and dry mid-facial skin Scaly patches on the scalp Blepharitis scaly red eyelid edges Pink, scaly plaques in skin folds each side of the face Ring shaped flaky patches on hair-line and chest Rash in armpits, under the breasts, in the groin folds, and genital creases Folliculitis (inflamed hair follicles) on cheeks and upper trunk What is the orthodox treatment for seborrheic dermatitis