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Still, many studies that are available were poorly designed

Neuroprotection: Semax may provide neuroprotective effects during ischemia by reducing inflammation-related gene expression and supporting neuronal survival

The British National Formulary (BNF), for example, differentiates the prescription of hydroxocobalamin according to presenting symptoms, eg, For neurological involvement, it is advised to administer hydroxocobalamin by intramuscular injection, initially 1 mg once daily on alternate days until no further improvement, then 1 mg every 2 months. In the Netherlands, pharmacotherapeutic guidelines51 recommend (for the same neurological symptoms or abnormalities) administration of 1000 mcg once or twice weekly for up to two years

Established osteoarthritis: Chronic progressive joint disease with ongoing cartilage degradation