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Combination therapy has shown somewhat higher rates of GI events compared to either monotherapy, and slow, gradual dose titration significantly improves tolerability

*Correspondence: Yan Yuan, [email protected] This article was submitted to Virology, a section of the journal Frontiers in Microbiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Of the 4,773 genes, 695 encoded function-altering amino acid changes that were specific to the whale lineage (Supplementary Table 36)