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Persistence in antigen expression could differentiate vaccines employing adenovirus vectors from the rest, and this feature is thought to favor the generation of long-term immune responses and prolonged immunity (82, 85)

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Since the first two pathways is mainly related to the concentration difference of intracellular and extracellular solutes rather than a regulatory role of the cell itself, the low permeability of BBB is achieved primarily by the efflux effects of ABCs and the inefficient vesicle transport

Geier DA, King PG, Hooker BS, Drea JG, Kern JK, Sykes LK, Geier MR (2015) Thimerosal: clinical, epidemiologic and biochemical studies