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Notably, NNMT expression has been found to be positively correlated with LDL levels and negatively correlated with HDL levels, both of which are relevant factors in cardiovascular diseases (Herfindal et al., 2020

The peptide also increased expression of beta-3 adrenergic receptor RNA in fat cells of obese mice to levels comparable with lean mice, suggesting it helps normalize the fat-burning machinery that obesity suppresses