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In cancer, inducers of ferroptosis, such as erastin and RSL3, take advantage of the high levels of iron and PUFAs in tumor cells [94, 95], while inhibitors like fer-1 and liproxstatin-1 show potential in treating neurodegenerative diseases, including Alzheimers, where lipid peroxidation contributes to neuronal damage [96]

Similarly, GSH-activatable synthetic ion channels undergo GSH-mediated disassembly to release channel-forming compounds, leading to caspase-dependent apoptosis 217

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Hcy meets with the methyl group provided by 5-Methyltetrahydrofolic acid (derived from folic acid) or betaine to produce methionine catalyzed by methionine synthase (MS)