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In addition to the cohort studies, four meta-analyses confirmed a higher frequency of vitamin B12 deficiency in patients with T2D taking metformin [28-31]

We excluded duplicated studies, studies which mixed men and women, and studies using weak androgens such as dehydroepiandrosterone or androstenedione

139 Guideline Statement 15 Clinicians should counsel patients who are considering pentosan polysulfate sodium on the potential risk for macular damage and vision-related injuries

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