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On the other hand, closed comedones, commonly referred to as whiteheads, are primarily a result of excess sebum production and the accumulation of dead skin cells that block hair follicles

115 116 Mechanistically, alcohol-induced CYP2E1 overexpression enhances HBV replication by upregulating hepatocyte nuclear factor-4, the key transcription factor for the HBV core promoter, 117 and increases HCV-related mitochondrial ROS, reducing antioxidant capacity and depleting mitochondrial glutathione, which heightens oxidative damage and cell death

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doi: 10.1016/j.biopha.2016.04.022 67 TortorellaSMRoyceSGLicciardiPVKaragiannisTC