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in these settings, ICA reduces intratumoral Treg infiltration and enhances CD8 + T cell cytotoxicity, even overcoming the inherent immunotherapy resistance of MSI-L tumors

and restriction endonucleases and modifying enzymes were purchased from New England Biolabs (Mississauga, Canada)

These bacterial groups engage in metabolic interactions with butyrate-producing bacteria, forming a complex cross-feeding network (Figure 5)

IJRAR-Int J Res Anal Rev 8(1):183199 Lazarevi S, anic M, Al-Salami H, Mooranian A, Mikov M (2022) Gut microbiota metabolism of azathioprine: a new hallmark for personalized drug-targeted therapy of chronic inflammatory bowel disease