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362 Primary resistance refers to tumors that exhibit minimal or no response to standard treatments, including chemotherapy, targeted therapy, or immunotherapy, from the start of treatment

As secondary symptoms, many MdDS patients develop anxiety and depression 4,24

The following adverse reactions have occurred with benzodiazepine abuse and/or misuse: abdominal pain, amnesia, anorexia, anxiety, aggression, ataxia, blurred vision, confusion, depression, disinhibition, disorientation, dizziness, euphoria, impaired concentration and memory, indigestion, irritability, muscle pain, slurred speech, tremors, and vertigo