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Since the glycation process occurs particularly in endothelial cells, the lens, kidneys and lungs, further long-term studies should verify the effect of amlodipine on preventing organ complications

This modulation influenced microbial metabolism and peripheral inflammation, regulated the activation state and functionality of microglia, and thereby reduced neuroinflammation and amyloidosis

Even physiological concentrations of soluble UA have been proved to induce gene expression of macrophage-secreted inflammatory cytokines and stimulate production of reactive oxygen species in mature adipocytes

Braddock, 2001), the transcription of other genes, including those for collagen II (1) and PDGF (Alexander et al., 2002)