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Disulfides are cleaved reductively by -mercaptoethanol, dithiothreitol, or TCEP, or oxidatively by performic acid reagents widely used in protein structure analysis

have constructed mice with cardiomyocyte-restricted deletion of subunit 1 of MPC (cMPC1 / )

In preclinical models, simultaneous deficiency in NAD+ and GSH is associated with accelerated mitochondrial dysfunction