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Promising signals are a starting point for investigation not a substitute for robust human efficacy data

PubMed Silverstein FE, et al

Peptide signals can elevate homing factors such as SDF-1 and induce the expression of niche signals that direct stem cells toward epithelial or germ-line cell fates

continued using Bmal1 knockout mice and reported altered clock gene expression (Cry2 and Per2) along with decreased Nrd1, Dbp, Il1 , and Nox2 expression and increased Gsr and Lpl expression, indicating that Bmal1 regulates immune response and cellular metabolism in microglia (Wang et al., 2020)