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Multiple observational studies have found that individuals with low B12 are significantly more likely to report depressive symptoms, and intervention studies show that correcting the deficiency improves mood outcomes sometimes substantially

the initial hybridised population may have experienced up to a 94% reduction in fitness compared to contemporary humans

The L66 mouse line, which overexpresses the full-length human tau with double mutations (P301S/G335D), demonstrates reduced nest building and sucrose preference at 5-6 months old, suggesting apathy-like deficits (Melis et al., 2015

HommelgaardAMRoepstorffKVilhardtFTorgersenMLSandvigKvan DeursB