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Aldose reductase and polyol pathway [19], [NADPH: Nicotinamide adenine Download Scientific Diagram 7 While the increased osmotic load of sorbitol was initially felt to be a part of the pathogenesis of diabetic complications, it's less clear that this plays a role. Instead, something else The four hyperglycemia related pathways: 1) polyol pathway with Download Scientific Diagram Polyol pathway. Hyperglycaemia increases flux through the polyol Download Scientific Diagram

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