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These immune responses, including the release of pro-inflammatory cytokines (e.g., TNF-, IL-1), can signal to the brain via the vagus nerve and the systemic circulation (Ma et al., 2020)

J Leukoc Biol (2013) 93(2):17584.10.1189/jlb.0912468 27 BodeLMcGuireMRodriguezJMGeddesDTHassiotouFHartmannPEet alIts alive: microbes and cells in human milk and their potential benefits to mother and infant