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Updated November 14, 2024

The RMS fluctuations suggest that overall, there is no structural deformation in the protein conformation observed and the fluctuations in the amino acid atom numbers can be accounted for from the interaction nanotube side-wall and the edges

Additionally, all three compounds increased antioxidant enzyme activity (SOD, APX and CAT), with melatonin showing the highest increases (25 %, 42.86 % and 31.5 %)

A possible explanation for these studies is that alterations in SCFA content in AS patients lead to impaired Treg function, which results in activation of the IL23-IL17/22 axis and dysregulation of mucosal cells involved in type 3 immunity and regulated by RORt (e.g., ILC3, invariant natural killer T (iNKT) cells, MAIT cells, and -T cells) (147)