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In order to test a possible effect of intracellular glutathione synthesis in such a process, buthionine sulfoximine (BSO), a specific the inhibitor of gamma-glutamylcysteine synthetase, was used to block the first step of intracellular glutathione synthesis

Sheridan et al., 2011

doi: 10.3390/vaccines4020012 18 ZhaoTCaiYJiangYHeXWeiYYuYet al

Clear regulatory guidelines and early engagement with agencies are also being pursued to ensure that promising ferroptosis-based CVD therapies can enter clinical trials and, ultimately, patient care