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Finally, the role of polyphenols in the clinical context of IBDs, along with the main problematics regarding their translational issues and concerns will be discussed, including bioavailability, their inclusion in healthy dietary patterns and foods, interaction with other drugs, and other important points to be addressed by future research

Heterolytic cleavage : they are generated via the non-uniform breaking (heterolysis) of a covalent bond, where the carbon atom retains both bonding electrons from a less electronegative group

Optimal results require minimum 16-week protocols, ideally extended to 6+ months for comprehensive evaluation