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Furthermore, esculin treatment significantly downregulated IL-1 expression, indicating its potential to modulate macrophage-driven inflammatory responses, likely through inhibition of critical signaling pathways such as NF-B

PRP: What It Actually Does PRP, or platelet rich plasma, is prepared from a small draw of your own blood and reintroduced into the skin through the same micro channels created during microneedling

Rocha GZ, Dias MM, Ropelle ER, Osrio-Costa F, Rossato FA, Vercesi AE, Saad MJA, Carvalheira JBC (2011) Metformin amplifies chemotherapy-induced AMPK activation and antitumoral growth

Institutional Review Board Statement This study was approved by the Institutional Review Board (IRB) of the Western University of Health Sciences (IRB protocol 08/IRB/019)