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Adoptive transfer of leukocytes from metastatic lymph nodes into tumor-nave recipients that were then challenged with a model of experimental metastasis showed enhanced progression of metastases in the lung, suggesting systemic immunosuppression caused by leukocytes from the metastatic lymph nodes ( TDLNs in immunotherapy TDLNs in anti-cancer immune response In the last decade, the landscape of cancer treatment has undergone significant changes, primarily driven by the progress of immunotherapy

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doi: 10.1038/nrm3507