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Throughout the pathological progression of autoimmune diseases, programmed cell death mechanisms such as autophagy, apoptosis, and pyroptosis predominantly contribute to chronic inflammation, tissue damage, and organ dysfunction [8,9,10,11]

Studies have shown that EC conjugation with hydrophobic proteins like soy lipophilic protein (Sun et al., 2023) or with dialdehyde starch (Yong et al., 2022) can significantly enhance its stability and antioxidant activity

Conjugated or direct bilirubin will increase in association with cholestatic diseases, in which bilirubin is conjugated but its excretion is impaired

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