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Future research should focus on patients who are critically ill for an extended period, on patients who may be at risk of developing central hypoadrenalism and on novel strategies to prevent and treat this complication

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Magnesium is required for every step of Vitamin D metabolism

Increased risk of breast tissue tumors and other hormone-sensitive cancers (such as prostate and pituitary cancers) Changes in fertility (decreased ability to produce sperm) Warnings and Special Considerations The use of GAHT increases the risk of blood clots, including deep vein thrombosis and pulmonary embolism