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Emerging evidence also indicates an increased risk of HA in patients treated with VPA and carbonic anhydrase inhibitors (CAIs) such as topiramate (TPM) and acetazolamide (ACZ) [15,16,17]

(4) The hydrolytic stability and reactivity of the PEG modifier depend on the stability of the activating group and the control of the modification reaction conditions, especially the pH

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The amino acid cysteine actively contributes to cancer metabolic remodelling on three different levels: first, in its free form, in redox control, as a component of the antioxidant glutathione or its involvement in protein s -cysteinylation, a reversible post-translational modification