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Different in vitro BBB cell culture models including primary and immortalized brain endothelial cell models, have been developed to facilitate the investigation of drug permeation across the BBB (199)

Overall, these studies highlight the importance of non-pharmacological interventions and in particular aerobic exercise and resistance training, possibly personalized and supervised, in the treatment of fibromyalgia and provide insights into the association with different approaches to alleviate symptoms and improve quality of life

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